Need Help With Major Infection -- Cause Unknown

That confirms the Eset detection is a False Positive, so the file can be left alone.

We now need to clean up the tools used.

To uninstall ComboFix, press the WINKEY + R keys on your keyboard or click > Run... and in the Open dialog box, type: ComboFix /Uninstall

• Press OK.
  -- Vista/Windows 7 users refer to these instructions.
• If you encounter any problems using the switch from the Run dialog box, just rename ComboFix.exe to Uninstall.exe, then double-click on it to remove.
• This will delete ComboFix's related folders/files, reset the clock settings, hide file extensions/system files, clear the System Restore cache to prevent possible reinfection and create a new Restore point.
• When it has finished you will see a dialog box stating that "ComboFix has been uninstalled".
• After that, you can delete the ComboFix.exe program from your computer (Desktop).

• Next
• Download OTC by OldTimer and save it to your desktop.
• Double click icon to start the program.
  If you are using Vista or Windows 7, please right-click and choose Run as Administrator
• Then Click the big button.
• You will get a prompt saying "Begin Cleanup Process". Please select Yes.
• Restart your computer when prompted.

-- Doing this will remove any specialized tools downloaded and used. If OTC does not delete itself, then delete the file manually when done.
-- Any leftover folders/files related to ComboFix or other tools which OTC did not remove can be deleted manually (right-click on it and choose delete).

Please post back when this is complete and let me know if you have had any problems.