not a valid win32 application

hello all, i have some nasty stuff going on with my laptop. I clean friends and co workers pc's and laptops all the time usually with combofix and adwcleaner. this one is on the wifes laptop and for the life of me i cant get rid of the mess. Ive ran combofix and it cleared out a few files. the problem is adwcleaner and other similar programs from bleepingcomputer. I get " ...exe is not a valid Win32 application "
Ive tried tdss killer and others with the same error message.

any help or guidance is greatly appreciated.
Thank you for any assistance

-Steve-